Maytansinoids

Maytansine and its derivatives (named as maytansinoids in general) are members of the ansamycins superfamily and contains a 19-member macrocyclic lactams attached to a chlorinated benzene. Maytansine is originally isolated from an Ethiopian shrub Maytenus ovatus and exerts extremely high anti-mitotic potency. Maytansinoids are microtubule-targeting agents that share same binding site with vinca and function by depolymerizing microtubules and arresting cells in the mitosis stage.Currently, several antibody-maytansinoid conjugates are under evaluation in clinical trial stages while many more are under active development in pre-clinical pipelines. Based on our well-established “DrugLnk” synthesis platform and extensive experience in ADC preparation, Creative BioLabs can help create unique antibody-maytansinoid conjugates with optimized linkers to meet your requirements. In the meantime, Creative BioLabs also provides various other ADC-related services. Please feel free to contact us for more information and a detailed quote regarding your ADC design and production. Creative Biolabs provides highly customized antibody-drug conjugate (ADC) production services using maytansinoids as payloads to meet your special requirements. https://www.creative-biolabs.com/adc/maytansinoids.htm