Microtubule Toxins

As a next-generation cancer immunotherapeutic strategy, antibody-drug conjugates (ADCs) combines the targeting specificity of a monoclonal antibody with the high toxicity of a payload drug to achieve discriminated cancer cell elimination. Payload drugs disrupt important cellular pathways and result in cell death by apoptosis. Microtubule is a key intracellular target for a variety of payload drugs. With a deep understanding of the payload structure, chemistry, and effects, Creative Biolabs provides customized ADCs development using microtubule toxins as payloads, which include auristatins, epothilone, maytansinoids, taxoids, tubulysins, and vinorelbine. Creative Biolabs provides a variety of cytotoxic payloads targeting microtubules for antibody-drug conjugates development. https://www.creative-biolabs.com/adc/microtubule-toxins.htm