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Anti-HMW-MAA scFv h(CD28-OX40-CD3ζ) CART, pCDCAR1
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https://www.creative-biolabs.com/car-t/pcdcar1-hmw-maa-h-28oxζ-t-216.htm The vector of anti-HMW-MAA chimeric antigen receptor (CAR) is constructed for the engineering of T cells to target human HMW-MAA. The T cells are genetically modified through transduction with a lentiviral vector expressing scFv of anti-HMW-MAA antibody linked to CD28 transmembrane domain/ endodomain and OX40, CD3-zeta signaling domains. And the vector product was designed for the treatment of metastatic melanoma.
